Thursday, June 15, 2017

Modafinil Combinations

Modafinil is a non-stimulant wakefulness enhancer that’s used clinically to treat disorders that make you sleepy or obstruct your normal sleep cycle. It offsets the grogginess caused by obstructive sleep apnea, narcolepsy, and other related conditions. In addition to its medical use, modafinil is increasingly used by college students and entrepreneurs to increase productivity and intellectual performance.

It’s important to consider drug-drug interactions when taking modafinil. Modafinil can even interact with certain foods. In this article, we’ll discuss the effects of combining modafinil with various substances, so that you can safely get the most out of your modafinil use.


Modafinil and Weed (Marijuana)





Taking modafinil with weed is not an unheard of recreational combination. It’s also likely that the THC in weed will offset the cognitive enhancing effects of modafinil.



Here’s one experience report from a Quora user who frequently combines modafinil with weed [8]:


Initially, the effect of the cannabis seems normal when you’re climbing into the high.

After about a half hour, the effects of the cannabis seem to heighten by a LOT. Your senses are heightened and you feel really in-tune with everything that’s going on.

The normal drowsiness and sleepiness that tend to come with most cannabis strains are totally absent. You feel fully awake and alert.

The cloudiness/fogginess/sluggishness often associated with cannabis are totally absent. Your body may feel a little slow but your mind will be fully alert and active.



To summarize, modafinil enhances the effect of cannabis, while decreasing fatigue. This could almost be considered an improvement on the intoxicating effects of cannabis alone.



On the other hand, cannabis also makes it easier to fall asleep after taking modafinil. This is actually a good thing, because many modafinil users report residual insomnia even 12 hours after taking modafinil. Maybe, much like Armodafinil (R-Isomer), we may finally get S-Modafinil (S-Isomer). As Armodafinil was created to last longer, S-Modafinil would have a shorter half-life, and may be more beneficial for those who find that Modafinil and Armodafinil keep them awake at night. You can find the Reddit discussion on this topic here.

One study directly investigated the safety of combining modafinil and oral THC. Twelve male and female occasional cannabis drug users participated in an outpatient double-blind, placebo-controlled, crossover study. The authors reported that oral THC raised heartbeat, and increased subjective evaluations of feeling “high” and “sedated,” in addition to self-reported euphoria. Modafinil alone raised the Profiles of Mood States (POMS) subscales of energy and tension. The study concluded that modafinil can most likely be safely taken alongside THC [9].